Vasodilator and activator

of cerebral metabolism

Brain disorders

Brain Disorder - Hypoxia

It should now be evident why unconsciousness rapidly occurs if breathing stops, or brain blood flow is interrupted even briefly.

As the delivery of oxygen to the brain halts, neurons rapidly shift from aerobic to anaerobic energy metabolism, with a consequent drop in energy production, up to 95%! There will simply not be enough ATP energy to facilitate neuronal electrical activity and neurotransmitter discharge- the electrochemical basis for consciousness. And if aerobic metabolism ceases for too long, eventually either irreparable damage or even cell death may occur, as even the 'housekeeping-maintenance' neuronal activities fall behind or fail due to energy shortage.

For most of us, falling unconscious or suffering brain death due to cessation of breathing or brain blood flow is not a regular problem to contend with! However, a more subtle, insidious, slow-developing form of brain energy crisis can and does occur in most people to some degree over a lifetime, in the form of cerebral arteriosclerosis, ministrokes, or transient ischaemic attacks (brief interruptions of brain blood supply, often due to blood vessel spasm).

In its early stages, this brain energy crisis may lead to only the slightest of symptoms-subtle memory impairment such as (there are more but just highlight three):

  • Occasional confusion.
  • Lapses in concentration.
  • Slightly more difficulty in learning.

At a more advanced stage the brain energy crisis may show itself as senility or senile dementia, and eventually may terminate in coma or death.

Thus as Branconnier notes "...the severity of the dementia is directly correlated to the loss of functional brain tissue, independent of the primary neuropathology. This view is consistent with evidence from stUdies of cerebral blood flow, oxygen uptake, and glucose utilization that have shown that brain carbohydrate metabolism (BC M) is impaired in a variety of dementias and that the degree of reduction in BCM is correlated with the severity of the dementia..."1

Orthomolecular psychiatry pioneer Abram Hoffer has suggested that when the brain oxygenation becomes chronically deficient enough, neurons switch to anaerobic glycolysis as their main energy source. This may provide (barely) enough energy for the neurons to survive, but it will not provide enough energy to power their functional roles as electrochemical signal processors! transmitters. Then the affected neurons will be 'off-line,' in an electrically quiescent 'idling' state.

However, if normal aerobic metabolism is restored before irreparable cell damage or death occurs, then the neurons and their functions can be restored.2

1. R. Branconnier (1983) "The efficacy of the cerebral metabolic enhancers in the treatment of senile dementia." Psychopharm Bull 19, 212-19.

2. A. Hoffer & M. Walker, Smart Nutrients, Garden City Park, N.Y.: Avery, 1994.

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